The effects of citicoline and/or MK-801 on survival, neurological and behavioral outcome of mice exposed to transient hyperglycemia and oligemic hypoxia
K. Rejdak et al., The effects of citicoline and/or MK-801 on survival, neurological and behavioral outcome of mice exposed to transient hyperglycemia and oligemic hypoxia, EUR NEUROPS, 11(5), 2001, pp. 333-341
The effects of citicoline and/or low dose of MK-801 (sufficient to prevent
the development of seizures) on survival, neurological and behavioral recov
ery following transient hyperglycemic-oligemic-hypoxic insult have been eva
luated in mice. Neurological recovery was assessed semi-quantitatively on t
he third and the 10th day after the insult, and behavioral tests evaluating
spontaneous locomotor activity, motor coordination and spontaneous alterna
tion performance were performed on day 10. Neither drug given alone did inf
luence survival rate, but the combination of MK-801 and higher citicoline d
ose decreased mortality on day 10. Behavioral performance was markedly comp
romised by the insult. Citicoline, but not MK-801, slightly but significant
ly improved behavioral outcome in all three tests. Conclusion: when brain i
schemic insult is complicated with acute hyperglycemia, post-treatment with
citicoline combined with MK-801 in low anti-convulsive dose improves survi
val and neurological recovery, and citicoline but not MK-801 enhances behav
ioral recovery. (C) 2001 Elsevier Science B.V. All rights reserved.