Contrasting influences of glucuronidation and O-methylation of epicatechinon hydrogen peroxide-induced cell death in neurons and fibroblasts

Authors
Spencer, JPE Schroeter, H Crossthwaithe, AJ Kuhnle, G Williams, RJ Rice-Evans, C
Citation
Jpe. Spencer et al., Contrasting influences of glucuronidation and O-methylation of epicatechinon hydrogen peroxide-induced cell death in neurons and fibroblasts, FREE RAD B, 31(9), 2001, pp. 1139-1146
Citations number
51
Categorie Soggetti
Biochemistry & Biophysics
Journal title
FREE RADICAL BIOLOGY AND MEDICINE
ISSN journal
08915849 → ACNP
Volume
31
Issue
9
Year of publication
2001
Pages
1139 - 1146
Database
ISI
SICI code
0891-5849(20011101)31:9<1139:CIOGAO>2.0.ZU;2-D
Abstract
The purpose of this study was to examine the comparative mechanisms by whic h the dietary form of the flavonoid epicatechin and its predominant in vivo metabolite, epicatechin glucuronide, influence oxidative stress-induced ce ll death in fibroblasts and neurons. The results demonstrate the contrastin g influences of in vivo glucuronidation and methylation on the bioactivity of epicatechin. (C) 2001 Elsevier Science Inc.