Novel germline RET mutation segregating with papillary thyroid carcinomas

The RET proto-oncogene is responsible for inherited medullary thyroid cance r syndromes. RET is also found mutated in sporadic medullary thyroid cancer (MTC) and rearranged in sporadic papillary thyroid carcinomas. Here, we de scribe a previously unreported germline RET mutation at codon 603 in exon 1 0 associated with both MTC and nonmedullary thyroid cancer (NMTC) in a kind red. RET may thus not be excluded as a potential candidate for predispositi on to some forms of NMTC. (C) 2001 Wiley-Liss, Inc.