High early death rate in tuberculosis patients in Malawi

SETTING: Thirty-eight district and mission hospitals in Malawi. OBJECTIVES: In patients registered with all types of tuberculosis (TB) in 1997 to dete rmine 1) treatment outcomes, and 2) when in the course of anti-tuberculosis treatment TB deaths occurred. DESIGN: A retrospective study using informat ion from TB registers, health centre registers, TB treatment cards and TB w ard admission books. RESULTS: A total of 16004 patients were registered with all types of TB, 64 71 with smear-positive pulmonary tuberculosis (PTB), 5305 with smear-negati ve PTB and 4228 with extra-pulmonary tuberculosis (EPTB). Of patients with all types of TB, 3720 (23%) died: death rates were 22% in smear-positive PT B, 26% in smear-negative PTB and 22% in EPTB. Month of death was known in 3 371 patients (91% of those who died) and day of death in 3326 patients (89% of those who died). In patients who died, 19% of deaths occurred by day 7 and 41% by the end of the first month of treatment. A higher proportion of early deaths occurred in patients with smear-negative PTB and EPTB and in r elation to increasing age. CONCLUSIONS: There was a high overall death rate in TB patients registered in 1997, with 40% of deaths occurring in the first month of treatment. Stra tegies to combat this problem are needed.