Prostate adenocarcinoma producing syndrome of inappropriate secretion of antidiuretic hormone

The syndrome of inappropriate secretion of antidiuretic hormone (ADH) was r ecognized in a 68-year-old man with a poorly differentiated metastatic aden ocarcinoma of the prostate. Elevated levels of ADH were found in the tissue s of the primary tumor and lymph node metastasis. The patient's clinical co urse is detailed and the pathophysiology of this syndrome is discussed. To our knowledge, this case is the ninth reported case of syndrome of inapprop riate secretion of ADH with adenocarcinoma of the prostate. Antidiuretic ho rmone activity was proven in only three cases including this case.