TREATMENT OF A DOG WITH AN INSULINOMA-RELATED PERIPHERAL POLYNEUROPATHY WITH CORTICOSTEROIDS

A crossbreed dog with a history of a chronic progressive tetraparesis had an insulinoma-related peripheral polyneuropathy. Frequent feeding and treatment with corticosteroids resulted in recovery from a non-amb ulatory to an almost completely normal clinical state, despite the per sistence of hypoglycaemia and hyperinsulinism, After euthanasia for un controllable seizures, the presence of a beta-cell carcinoma of the pa ncreas and extensive axonal degeneration of the peripheral nerves was confirmed by histopathological examination. These findings may indicat e an immune-mediated pathogenesis for insulinoma-related peripheral po lyneuropathy.