Autologous peripheral stem-cell transplantation after intensive chemotherapy in a case of CD30 (Ki-1)-positive anaplastic large-cell lymphoma

Simultaneous treatment with peripheral blood stem-cell (PBSC) transplantati on and intensive chemotherapy was evaluated in a case of non-Hodgkin's lymp homa (NHL) with poor prognosis. A 59-year-old male diagnosed with a high-gr ade, anaplastic large-cell (Ki-1) NHL, involving fractures in the left hip, underwent computed tomography and gallium scintigram surveillance. The pat ient received chemotherapy with epirubicin hydrochloride, cyclophosphamide, vincristine and prednisolone, and the fractured hip bone was repaired foll owing the first course of chemotherapy. After the second and third courses of chemotherapy, PBSCs were harvested and cryopreserved. The patient then r eceived a further course of chemotherapy and PBSC transplantation was condu cted using infused cells consisting of 9.63 x 10(6)/kg CD34 cells and 2.24 x 10(5)/kg granulocyte macrophage colony-forming units. Recovery of platele t and white blood cell counts occurred 10 and 8 days, respectively, after P BSC infusion and the patient remains well.