A behavioural pattern analysis of hypoglutamatergic mice - effects of fourdifferent antipsychotic agents

In a hypoglutamatergic rodent model, we have observed certain behaviours th at might have relevance for the cognitive impairments seen in autism and sc hizophrenia. Thus, hypoglutamatergic mice show defective habituation, impai red attention, a meagre behavioural repertoire and a general behavioural pr imitivization. The aim of the present study was to characterise and quantif y changes in movement pattern in mice rendered hypoglutamatergic by means o f MK-801 treatment, using an automated video tracking system. Further, the effects of four different antipsychotic drugs, the classical neuroleptic ha loperidol, the atypical antipsychotic clozapine, the DA D2/5HT2A antagonist risperidone and the selective 5-HT2A-receptor antagonist M100907, were com pared with respect to effects on NMDA antagonist-induced movement pattern a lterations. We found that each receptor antagonist had a unique effect on the MK-801-in duced behavioural primitivization. Haloperidol was unable to affect the mon otonous behaviour induced by MK-801, while risperidone, clozapine and M1009 07 produced movement patterns of high intricacy.