INFLUENCE OF LONG-TERM SODIUM-FLUORIDE ADMINISTRATION ON SELECTED PARAMETERS OF RAT-BLOOD SERUM AND LIVER-FUNCTION

We investigated the effect of fluoride ion (F-) on selected parameters of blood serum and liver function in rats. Sodium fluoride was admini stered for periods of 3 and 6 months, respectively, via drinking water containing 10 and 30 ppm F-. We demonstrate that concentrations of fl uoride and glucose in blood serum are both universal indicators for mo nitoring fluoride poisoning in rats at the two F- concentrations and e xposure times used. Also, activities of some liver enzymes are of simi lar indicative value. These enzymes are: aspartate aminotransferase -A ST [GOT], alanine aminotransferase -ALT [GPT], ornithine carbamoyltran sferase [OTC], arginase [ARG], malate dehydrogenase [MDH] and isocitra te dehydrogenase [ICD].