E. Gruckamamczar et al., INFLUENCE OF LONG-TERM SODIUM-FLUORIDE ADMINISTRATION ON SELECTED PARAMETERS OF RAT-BLOOD SERUM AND LIVER-FUNCTION, Fluoride, 30(3), 1997, pp. 157-164
We investigated the effect of fluoride ion (F-) on selected parameters
of blood serum and liver function in rats. Sodium fluoride was admini
stered for periods of 3 and 6 months, respectively, via drinking water
containing 10 and 30 ppm F-. We demonstrate that concentrations of fl
uoride and glucose in blood serum are both universal indicators for mo
nitoring fluoride poisoning in rats at the two F- concentrations and e
xposure times used. Also, activities of some liver enzymes are of simi
lar indicative value. These enzymes are: aspartate aminotransferase -A
ST [GOT], alanine aminotransferase -ALT [GPT], ornithine carbamoyltran
sferase [OTC], arginase [ARG], malate dehydrogenase [MDH] and isocitra
te dehydrogenase [ICD].