Recombinant Newcastle disease virus as a vaccine vector

Authors
Nakaya, T Cros, J Park, MS Nakaya, Y Zheng, HY Sagrera, A Villar, E Garcia-Sastre, A Palese, P
Citation
T. Nakaya et al., Recombinant Newcastle disease virus as a vaccine vector, J VIROLOGY, 75(23), 2001, pp. 11868-11873
Citations number
38
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
75
Issue
23
Year of publication
2001
Pages
11868 - 11873
Database
ISI
SICI code
0022-538X(200112)75:23<11868:RNDVAA>2.0.ZU;2-K
Abstract
A complete cDNA clone of the Newcastle disease virus (NDV) vaccine strain H itchner B1 was constructed, and infectious recombinant virus expressing an influenza virus hemagglutinin was generated by reverse genetics. The rescue d virus induces a strong humoral antibody response against influenza virus and provides complete protection against a lethal dose of influenza virus c hallenge in mice, demonstrating the potential of recombinant NDV as a vacci ne vector.