Interleukin-4 up-regulates mouse mammary tumor virus expression yet is notrequired for in vivo virus spread

Authors
Czarneski, J Meyers, J Peng, T Agraham, V Mick, R Ross, SR
Citation
J. Czarneski et al., Interleukin-4 up-regulates mouse mammary tumor virus expression yet is notrequired for in vivo virus spread, J VIROLOGY, 75(23), 2001, pp. 11886-11890
Citations number
42
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
75
Issue
23
Year of publication
2001
Pages
11886 - 11890
Database
ISI
SICI code
0022-538X(200112)75:23<11886:IUMMTV>2.0.ZU;2-E
Abstract
The mouse mammary tumor virus (MMTV) superantigen induces T-cell production of cytokines, such as interleukin-4, which in turn increase MMTV transcrip tion. However, interleukin-4 is not required for in vivo virus spread, beca use mice lacking interleukin-4 or the STAT6 transcription factor showed wil d-type infection of lymphoid and mammary tissue. In spite of this, mammary tumor incidence was decreased in STAT6 null mice.