LIPOPROTEIN GLYCATION AND ITS METABOLIC CONSEQUENCES

Glycation of lipoproteins is implicated in the development of the macr o- and microvascular complications of diabetes, atherosclerosis in gen eral, and other disease processes including aging. Enhanced glycation may have direct effects, and may also amplify the effects of oxidative stress on lipoproteins, Most studies have examined the effects of gly cation of LDL, particularly with respect to its atherogenicity, Other lipoproteins are more difficult to study because their several apolipo proteins, being of varying age, are not uniformly exposed to glucose. Inhibition of the combined stresses of glycation and oxidation towards lipoproteins may have beneficial effects an health.