Purpose: To quantitatively analyze in vitro the fluoride release from
proximal VariGlass restorations and resulting uptake by the enamel of
adjacent teeth. Materials and Methods: Sixty impacted third molars wer
e used and assigned to three groups: C: control, teeth without restora
tions; RC: teeth with resin composite restorations (Prisma APH); and P
MRC: teeth with polyacid-modified resin composite restorations (VariGl
ass). Each group consisted of four sets of five teeth each. In the lat
ter two sets, by alternating restored and unrestored teeth, the proxim
al surfaces of three unrestored teeth with an area of exposed enamel w
ere in contact with the restored proximal surfaces of two other teeth.
The sets were submitted to high caries challenge conditions with demi
neralizing and remineralizing solutions for 14 days. The fluoride of e
ach solution and the fluoride uptake were determined and statistical a
nalyses were carried out (ANOVA and Tukey's test). Results: The highes
t mean fluoride concentration occurred with Group PMRC in both kinds o
f solutions (P < 0.01), but this value was higher in the demineralizin
g solution (P < 0.01). Over the 14 days, however, this mean gradually
decreased in both solutions (P < 0.01). Group PMRC also showed the hig
hest mean fluoride uptake (P < 0.01), which gradually decreased with d
epth in the enamel (P < 0.01).