Infantile nephrotic syndrome and congenital glaucoma

A case of infantile nephrotic syndrome (NS) with advanced membranoprolifera tive glomerulonephritis (MPGN), type I, and bilateral congenital glaucoma, is presented. The patient also had persistent thrombocytopenia and subclini cal hypothyroidism. The parents were second-degree cousins and the affected infant had a sibling who was born with congenital glaucoma. His mother had an aunt and uncle on the maternal side who were born with congenital glauc oma. In addition, there was a history of infantile death in five family mem bers of unknown causes (pedigree). To the best of our knowledge, the associ ation of congenital glaucoma and infantile NS due to MPGN has not been repo rted previously.