Intravenous immunoglobulin for cranial polyneuropathy associated with Campylobacter jejuni infection

This study reports the efficacy of IV immunoglobulin in a patient with cran ial polyneuropathy resulting from Campylobacter jejuni infection who had hi gh titers of serum IgG antibodies against gangliosides GD1a and GT1b in the acute phase. Treatment with IV immunoglobulin (400 mg/kg/day x 5 days) led to rapid partial resolution of his neurologic manifestations, but complete recovery was not obtained until 6 months later. The present case suggests that IV immunoglobulin therapy prevents further progression of the disease but that it may not shorten the clinical course of cranial polyneuropathy i n some cases associated with Campylobacter jejuni infection. (C) 2001 by El sevier Science Inc. All rights reserved.