Synthesis of certain 6-(arylthio)uracils as potential antiviral agents

Authors
El-Emam, AA Nasr, MNA Pedersen, EB Fouad, T Nielsen, C
Citation
Aa. El-emam et al., Synthesis of certain 6-(arylthio)uracils as potential antiviral agents, PHOSPHOR SU, 174, 2001, pp. 25-35
Citations number
23
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
ISSN journal
10426507 → ACNP
Volume
174
Year of publication
2001
Pages
25 - 35
Database
ISI
SICI code
1042-6507(2001)174:<25:SOC6AP>2.0.ZU;2-6
Abstract
A series of 6-(Arylthio)uracils have been prepared via condensation of 6-ch lorouracil or 5-ethyl-6-chlorouracil with the corresponding thiophenol deri vatives in pyridine or ethanolic potassium hydroxide. The synthesized compo unds were tested for their antiviral activity. Some of the 5-ethyl-6-(arylt hio)uracil derivatives 10a-g showed moderate activities against hepatitis B Virus, (HBV) and HIV-1 virus.