The novel syntheses of alpha-trifluoromethylated ketones from beta-bromoenol phosphates

Authors
Huang, XG He, YT Ding, YX
Citation
Xg. Huang et al., The novel syntheses of alpha-trifluoromethylated ketones from beta-bromoenol phosphates, PHOSPHOR SU, 174, 2001, pp. 201-207
Citations number
28
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
ISSN journal
10426507 → ACNP
Volume
174
Year of publication
2001
Pages
201 - 207
Database
ISI
SICI code
1042-6507(2001)174:<201:TNSOAK>2.0.ZU;2-K
Abstract
A series of 1-aryl-3,3,3-trifluro-1-propanones have been synthesized from t he reaction of FO2SCF2CO2Me with beta -bromoenol phosphates in the presence of Cul in moderate yield. The reaction mechanism was discussion, the elect ron-withdrawing substituent at the beta -position of the enol phosphates pr omoted the catalytic cleavage of the O-P bond in enol phosphates by fluorid e ion.