Organophosphorus compounds as potential fungicides. Part VI. Preparation, characterization, and biological activity of analogues and derivatives of 1-aminopropanephosphonic acid
Hr. Hudson et al., Organophosphorus compounds as potential fungicides. Part VI. Preparation, characterization, and biological activity of analogues and derivatives of 1-aminopropanephosphonic acid, PHOSPHOR SU, 173, 2001, pp. 143-162
Citations number
31
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
alpha -Aminopropane-phosphonous, -methylphosphinic, and -phenylphosphinic a
cids do not exhibit comparable antifungal activity to that shown by alpha -
aminopropanephosphonic acid (ampropylfos) against Drechslera teres, when ap
plied as seed dressings, It is concluded that the phosphonic acid function
is necessary for this type of activity. Moderate activity against several o
rganisms was nevertheless shown by alpha -aminopropane- and alpha -aminoeth
ane-phosphonous acids in foliar spray tests, although longer chain compound
s were found to be inactive. alpha -Ureidopropanephosphonate (ammonium salt
) also showed activity in foliar tests at 1000 ppm. A range of new ureylene
- and thioureylene-bisphosphonates, prepared as potential profungicides of
ampropylfos, proved to be inactive as seed dressings although tetrakis(2,2,
2-trifluoroethyl) thioureylenebis(1-propylphosphonate) gave 75-100% control
of Puccinia recondita as a foliar spray (1000 ppm). Characterization of th
e various compounds by nmr spectroscopy and mass spectrometry is discussed.