TREATMENT OF MURINE DISSEMINATED CANDIDIASIS WITH L-743,872

Authors
GRAYBILL JR NAJVAR LK LUTHER MF FOTHERGILL AW
Citation
Jr. Graybill et al., TREATMENT OF MURINE DISSEMINATED CANDIDIASIS WITH L-743,872, Antimicrobial agents and chemotherapy, 41(8), 1997, pp. 1775-1777
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
41
Issue
8
Year of publication
1997
Pages
1775 - 1777
Database
ISI
SICI code
0066-4804(1997)41:8<1775:TOMDCW>2.0.ZU;2-N
Abstract
L-743,872 (M991), which is a pneumocandin derivative, was evaluated in a mouse model of disseminated candidiasis caused by a fluconazole-res istant isolate of Candida albicans, In immunocompetent mice M991 prolo nged survival at doses as low as 0.0125 mg/kg of body weight per day. In neutropenic mice 0.05 mg/kg was the lowest effective dose. M991 is a very potent drug for treatment of disseminated candidiasis.