Different statistical multifragmentation models have been used to study iso
scaling i.e., the factorization of the isotope ratios from two reactions, i
nto fugacity terms of proton and neutron number, R21(N,Z) =Y-2(N,Z)/Y-1(N,Z
)=Ce xp(alphaN+betaZ). Even though the primary isotope distributions axe qu
ite different from the final distributions due to evaporation from the exci
ted fragments, the values of alpha and beta are not much affected by sequen
tial decays. alpha is shown to be mainly sensitive to the proton-to-neutron
composition of the emitting source and may be used to study isospin-depend
ent properties in nuclear collisions, such as, the symmetry energy in the e
quation of state of asymmetric nuclear matter.