IN-VITRO ACTIVITIES OF TERBINAFINE IN COMBINATION WITH FLUCONAZOLE AND ITRACONAZOLE AGAINST ISOLATES OF CANDIDA-ALBICANS WITH REDUCED SUSCEPTIBILITY TO AZOLES

Authors
BARCHIESI F DIFRANCESCO LF SCALISE G
Citation
F. Barchiesi et al., IN-VITRO ACTIVITIES OF TERBINAFINE IN COMBINATION WITH FLUCONAZOLE AND ITRACONAZOLE AGAINST ISOLATES OF CANDIDA-ALBICANS WITH REDUCED SUSCEPTIBILITY TO AZOLES, Antimicrobial agents and chemotherapy, 41(8), 1997, pp. 1812-1814
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
41
Issue
8
Year of publication
1997
Pages
1812 - 1814
Database
ISI
SICI code
0066-4804(1997)41:8<1812:IAOTIC>2.0.ZU;2-Q
Abstract
A checkerboard microdilution method was applied to study the in vitro interaction of terbinafine with either fluconazole and itraconazole ag ainst 30 strains of Candida albicans. Synergy was observed in 40% of t he terbinafine-fluconazole interactions and in 43% of the terbinafine- itraconazole interactions, while antagonism was not observed, Even whe n only additivity was achieved, the combinations still showed benefici al effects since at least twofold reductions in the MICs of both drugs were found in 100% of the terbinafine-fluconazole interactions and in 76% of the terbinafine-itraconazole interactions.