We show that a string-inspired Planck scale modification of general relativ
ity can have observable cosmological effects. Specifically, we present a co
mplete analysis of the inflationary perturbation spectrum produced by a phe
nomenological Lagrangian that has a standard form on large scales but incor
porates a string-inspired short distance cutoff, and find a deviation from
the standard result. We use the de Sitter calculation as the basis of a qua
litative analysis of other inflationary backgrounds, arguing that in these
cases the cutoff could have a more pronounced effect, changing the shape of
the spectrum. Moreover, the computational approach developed here can be u
sed to provide unambiguous calculations of the perturbation spectrum in oth
er heuristic models that modify trans-Planckian physics and thereby determi
ne their impact on the inflationary perturbation spectrum. Finally, we argu
e that this model may provide an exception to constraints, recently propose
d by Tanaka and Starobinsky, on the ability of Planck-scale physics to modi
fy the cosmological spectrum.