VORICONAZOLE (UK-109,496) INHIBITS THE GROWTH AND ALTERS THE MORPHOLOGY OF FLUCONAZOLE-SUSCEPTIBLE AND FLUCONAZOLE-RESISTANT CANDIDA SPECIES

Authors
BELANGER P NAST CC FRATTI R SANATI H GHANNOUM M
Citation
P. Belanger et al., VORICONAZOLE (UK-109,496) INHIBITS THE GROWTH AND ALTERS THE MORPHOLOGY OF FLUCONAZOLE-SUSCEPTIBLE AND FLUCONAZOLE-RESISTANT CANDIDA SPECIES, Antimicrobial agents and chemotherapy, 41(8), 1997, pp. 1840-1842
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
41
Issue
8
Year of publication
1997
Pages
1840 - 1842
Database
ISI
SICI code
0066-4804(1997)41:8<1840:V(ITGA>2.0.ZU;2-G
Abstract
The effects of voriconazole on the growth, ultrastructure, and leakage of cytoplasmic materials of Candida species were investigated, MIC da ta showed that voriconazole was more active than fluconazole. Exposure of yeast to voriconazole caused growth inhibition, cell wall thinning , and cell membrane degradation. Neither cell collapse nor release of cytoplasmic materials was observed in the treated cells.