COMPARISON OF SINGLE-DOSE ORAL GREPAFLOXACIN WITH CEFIXIME FOR TREATMENT OF UNCOMPLICATED GONORRHEA IN MEN

In a randomized open study, 351 male patients with uncomplicated gonor rhea were given single oral doses of grepafloxacin (100 mg) or cefixim e (400 mg). In the 299 microbiologically evaluable patients, urethral infections were cured in 99% (147 of 149) of those receiving grepaflox acin and 97% (145 of 150) of those given cefixime. Eradication rates f or both regimens were 100% in the 16% (47 of 299) of participants who were infected with penicillin-resistant Neisseria gonorrhoeae and 97% in the 21% (62 of 299) of participants infected with tetracycline-resi stant strains. Grepafloxacin is a well-tolerated alternative to cefixi me for treatment of uncomplicated gonorrhea in males.