Synthesis of nucleoside analogs and new Tat protein inhibitors

Two studies, concerning the synthesis of original nucleoside analogs regard ed as an application of heterochemistry on thiaazaheterocycle systems from thiaazabutadienes are discussed. The preparation of new N- and C-nucleoside s is presented. In the second part, the discovery of aromatic polycyclic de rivatives as inhibitors of Tat protein is exposed. The work presented takes into account the participation of African partners in further synthetic re search programs carried out in collaboration with the laboratory of Nantes.