Research of anti-Aspergillus fumigatus and anti-moud precipitins. in the serum of horses suffering from exercice induced epistaxis syndrom.

Race horse's epistaxis syndrome induces bad performances and often restrict s sportive career of athlete. Its etio-pathogenic mechanism is not well elu cidate in spite of a many works devoted. The immuno-allergic compenant has been evoquated. The authors search for the precipitant antibodies directed towards Aspergil lus fumigatus (AF) and mouldy bay total extract (Fo. Moi) by electrocynaere sis on cellulose acetate membrane. Fo. Moi were obtained according to the P epys technic, AF are commercial antigens, (Diagnostics Pasteur). The diseas ed horses, at the number of 30, were racehorses that showed recurrent episo des of epistaxis after exertion. The diagnosis was realised on the basis of commemoratives and clinical examination associated, systematically, to end oscopic examination. The control horses, at the number of 49, are healthy h orses taking part at the races in the conditions than diseased horses. For each serum, a total score was attribuate to each antigen, Liking into accou nt the quality, the intensity and the number of precipitation arcs. The nil scores obtained toward the two antigens are comparable in healthy and dise ased horses. Neverless the mean positive scores toward Fo. Moi show a signi ficant difference between the 2 groups : horses with epistaxis show a mean level, 3.0 +/- 1.6, statically higher than those of control horses, 1.6 +/- 0.8. The distribution of Fo.Moi scores according to response intensity rev eal that horses with epistaxis have rather greatly positive responses, in f act 86 % of diseased horses have a score higher than a weakly positive type of responses. No horse with epistaxis, had reacted to AE The type III hype rsensitivity's phenomenons, toward Fo. Moi, could be one of causes interven ing in fitting out of epistaxis because we find more precipitin anti-Fo Moi with a greatly positive type of responses.