Synthesis and biological activity of some 1,3,2-diheteraphosphorinanes andtheir acyclic analogs

Methods were developed for the synthesis of 2-butylthio-2-oxo-1,3,2-oxazaph osphorinane, 2-butylthio-2-thioxo-1,3,2-dioxaphosphorinane, and 2-butylthio -2-thioxo-1,3,2-diazaphosphorinane, as well as of acyclic S-butyl O-ethyl ( diethylamido)phosphorothioates and -dithioates and S-butyl bis(diethylamido )phosphorodithioate. These compounds can serve as models of possible metabo lites of cyclic compounds. Based on the data obtained in studies of the ant iesterase activity of the resulting compounds and their synergistic activit y in mixtures with permethrine, a possible mechanism of in vitro and in viv o biological action of diheteraphosphorinanes was proposed.