Development of live recombinant vaccine candidates against tuberculosis

Authors
Hess, J Kaufmann, SHE
Citation
J. Hess et She. Kaufmann, Development of live recombinant vaccine candidates against tuberculosis, SC J IN DIS, 33(10), 2001, pp. 723-724
Citations number
9
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
ISSN journal
00365548 → ACNP
Volume
33
Issue
10
Year of publication
2001
Pages
723 - 724
Database
ISI
SICI code
0036-5548(2001)33:10<723:DOLRVC>2.0.ZU;2-6
Abstract
We report on 2 recombinant (r) live vaccine candidates that use different s trategies to improve cell-mediated immunity for TB control: (i) the current TB vaccine strain Mycobacterium bovis BCG, endowed with a pore-forming cyt olysin; and (ii) rSalmonella typhimurium secreting a single immunodominant antigen shared by BCG and M. tuberculosis.