A facile and versatile route to 2-substituted-4(3H)-quinazolinones and quinazolines

A range of 2-aryl and 2-alkyl quinazolinones have been prepared in moderate to good yields from the reaction of anthranilic acid and the appropriately substituted imidate in a facile, mild, one-pot procedure. Subsequent react ion with phosphorus oxychloride afforded the corresponding 4-chloro-2-subst ituted quinazolines, which are useful synthetic intermediates, in good to h igh yields. Product isolation was facilitated by the development of work up procedures for both reactions that did not include purification by column chromatography.