iPF(2 alpha)-III metabolism. First total synthesis of 2,3-dinor iPF(2 alpha)-III, a primary beta-oxidation metabolite

Authors
Kim, SJ Jung, YJ Lawson, JA FitzGerald, GA Rokach, J
Citation
Sj. Kim et al., iPF(2 alpha)-III metabolism. First total synthesis of 2,3-dinor iPF(2 alpha)-III, a primary beta-oxidation metabolite, TETRAHEDR L, 42(47), 2001, pp. 8277-8280
Citations number
24
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
47
Year of publication
2001
Pages
8277 - 8280
Database
ISI
SICI code
0040-4039(20011119)42:47<8277:IAMFTS>2.0.ZU;2-4
Abstract
The total synthesis of a primary iPF(2 alpha)-III metabolite, namely dinor iPF(2 alpha)-III 8, is described. The successful synthesis was finally acco mplished by generating the carboxylic acid group at the end of the synthesi s so as to avoid formation of an alpha,beta -unsaturated carboxylic acid, w hich is prone to undergo side reactions (C) 2001 Elsevier Science Ltd. All rights reserved.