HIV-1 replication inhibitors of the styrylquinoline class: incorporation of a masked diketo acid pharmacophore

Authors
Zouhiri, F Desmaele, D d'Angelo, J Ourevitch, M Mouscadet, JF Leh, H Le Bret, M
Citation
F. Zouhiri et al., HIV-1 replication inhibitors of the styrylquinoline class: incorporation of a masked diketo acid pharmacophore, TETRAHEDR L, 42(46), 2001, pp. 8189-8192
Citations number
12
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
46
Year of publication
2001
Pages
8189 - 8192
Database
ISI
SICI code
0040-4039(20011112)42:46<8189:HRIOTS>2.0.ZU;2-P
Abstract
A novel variant of HIV-1 replication inhibitors of the styrylquinoline clas s, bearing an alpha -keto acid appendage at C-7, has been synthesized. Thou gh completely inactive in in vitro experiments against HIV-1 integrase, thi s compound exhibited a significant antiviral activity (IC50 = 10 muM). (C) 2001 Elsevier Science Ltd. All rights reserved.