A convenient synthesis of symmetrical N,N '-dialkylureas by the reactions of 4-chloro-5H-1,2,3-dithiazol-5-one with alkylamines

Authors
Chang, YG Lee, HS Kim, K
Citation
Yg. Chang et al., A convenient synthesis of symmetrical N,N '-dialkylureas by the reactions of 4-chloro-5H-1,2,3-dithiazol-5-one with alkylamines, TETRAHEDR L, 42(46), 2001, pp. 8197-8200
Citations number
25
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
46
Year of publication
2001
Pages
8197 - 8200
Database
ISI
SICI code
0040-4039(20011112)42:46<8197:ACSOSN>2.0.ZU;2-8
Abstract
Treatment of 4-chloro-5H-1,2,3-dithiazol-5-one with primary and secondary a lkylamines (>2 equiv.) in CH2Cl2, at rt afforded symmetrical N,N'-disubstit uted ureas in moderate to good yields. Similarly, the reactions with amino acid ester hydrochlorides in the presence of Et3N (>3 equiv.) under the sam e conditions gave symmetrical ureas. (C) 2001 Elsevier Science Ltd. All rig hts reserved.