Nucleotide sequence of exons 2 and 3 of the novel HLA-Cw*12032 allele

Citation
Zm. Velickovic et Jm. Carter, Nucleotide sequence of exons 2 and 3 of the novel HLA-Cw*12032 allele, TISSUE ANTI, 58(2), 2001, pp. 97-98
Citations number
4
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
TISSUE ANTIGENS
ISSN journal
00012815 → ACNP
Volume
58
Issue
2
Year of publication
2001
Pages
97 - 98
Database
ISI
SICI code
0001-2815(200108)58:2<97:NSOE2A>2.0.ZU;2-R
Abstract
A novel HLA-C nucleotide sequence was discovered in an individual of Pacifi c Island, Tongan ethnicity using sequencing based typing. The sequence was given an official allele designation HLA-Cw*12032 by the WHO Nomenclature C ommittee for Factors of the HLA System. The novel sequence has 2 bp substit utions compared to the HLA-Cw*1203 at codon 134 "T" to "C" and codon 135 "C " to "G". However, when converted to amino acid sequences HLA-Cw*1203 and H LA-Cw*12032 are identical and would not have direct clinical implications.