Immunity against prions?

Citation
Fl. Heppner et al., Immunity against prions?, TRENDS MO M, 7(11), 2001, pp. 477-479
Citations number
12
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Journal title
TRENDS IN MOLECULAR MEDICINE
ISSN journal
14714914 → ACNP
Volume
7
Issue
11
Year of publication
2001
Pages
477 - 479
Database
ISI
SICI code
1471-4914(200111)7:11<477:IAP>2.0.ZU;2-B
Abstract
Several recent reports indicate that antibodies directed against the cellul ar form of the prion protein, PrPc, might eliminate the transmissible agent of spongiform encephalopathies (the prion) from scrapie-infected cells in vitro, and that a humoral immune response could prevent scrapie pathogenesi s in vivo. These findings suggest that immunotherapeutical intervention aga inst prion diseases is not unattainable. Will vaccines and post-exposure st rategies based on antibodies ever prove useful against scrapie, bovine spon giform encephalopathy (BSE), or Creutzfeldt-Jakob disease?.