Design of integrated crystallization systems

A systematic procedure is developed for designing an integrated crystalliza tion system by considering the interaction between crystallization and down stream processing. Potential problems related to unit operations such as fi ltration, washing, dewatering, recrystallization, and drying are anticipate d and resolved by determining an operating policy and configuration for the crystallizer as well as the downstream units. The approach can be applied to both batch and continuous crystallizers. First, the possible impacts of particle-size distribution (PSD) on the downstream processing units are ide ntified. This forms the basis for determining a target PSD in the second st ep. Third, possible means by which the desired PSD can be achieved are sele cted. Fourth, the alternatives thus generated are evaluated and compared to identify, the best design. Heuristics are provided along the way to guide the decision making. Shortcut equipment models are used to compare the perf ormance of the alternatives. The procedure is illustrated with two industri al examples, including the production of adipic acid.