The influence of process analyzer location and performance on plant-wide pr
ocess monitoring was evaluated using five uncertainty contributions to the
estimation error: measurement error/uncertainty, analysis frequency, sample
size/grab error, analyzer memory effect/response correlation, and delay ti
me. The choice of both the location and performance characteristics of diff
erent process analyzers can be evaluated using a measurability factor M, ra
nging from zero to one, where one indicates perfect monitoring capabilities
. Due to the unifying nature of the measurability factor, this factor can b
e used to make a rational decision between very different process analyzers
. This allows for finding optimal process analyzer configurations for exist
ing processes or for processes in the design phase. A tubular reactor simul
ation model was used for the partial oxidation of benzene to maleic anhydri
de to demonstrate the use of the measurability factor.