Achalasia is an esophageal motility disorder characterized by the failure o
f lower esophageal sphincter relaxation and the absence of esophageal peris
talsis. The purpose of this study was to evaluate the clinical outcomes of
patients undergoing laparoscopic esophageal myotomy and Toupet fundoplicati
on for achalasia. A 9-cm. myotomy was performed in most cases extending 7 c
m above and 2 cm below the gastroesophageal junction. Severity of dysphagia
, heartburn, chest pain, and regurgitation was graded preoperatively and po
stoperatively using a five-point symptomatic scale (0-4). Patients also gra
ded their outcomes as excellent, good, fair, or poor. Between December 1995
and November 2000 a total of 49 patients (23 male, 26 female) with a mean
age of 44.3 years (range 23-71 years) were diagnosed with achalasia. Mean d
uration of symptoms was 40.2 months (range 4-240 months). Thirty-seven pati
ents (76%) had had a previous nonsurgical intervention or combinations of n
onsurgical interventions [pneumatic dilation (23), bougie dilation (five),
and botulinum toxin (19)], and two patients had failed esophageal myotomies
. Forty-five patients underwent laparoscopic esophageal myotomy and Toupet
fundoplication. Two patients received laparoscopic esophageal myotomies wit
hout an antireflux procedure, and two were converted to open surgery. One p
atient presented 10 hours after a pneumatically induced perforation and und
erwent a successful laparoscopic esophageal myotomy and partial fundoplicat
ion. Mean operative time was 180.5 minutes (range 145-264 minutes). Mean le
ngth of stay was 1.98 days (range 1-18 days). There were five (10%) periope
rative complications but no esophageal leaks. There was a significant diffe
rence (P < 0.05) between the preoperative and postoperative dysphagia, ches
t pain, and regurgitation symptom scores. All patients stated that they wer
e improved postoperatively. Eighty-six per cent rated their outcome as exce
llent, 10 per cent as good, and 4 per cent as fair. Laparoscopic anterior e
sophageal myotomy and Toupet fundoplication effectively alleviates dysphagi
a, regurgitation, and chest pain accompanying achalasia and is associated w
ith high patient satisfaction, a rapid hospital discharge, and few complica
tions.