Cytogenetics of neuroblastoma: A study using fine needle aspiration cultures

Neuroblastoma is associated with chromosomal aberrations of lp and Iq in a majority of cases. Some nonrandom secondary chances were observed in this s tudy. The role of these changes in the development and progression of neuro blastoma is examined. Chromosomal analysis was performed on 33 children wit h neuroblastoma using fine needle aspiration cultures. Metaphases were obse rved in 57.5% of cases. 86.6% showed the involvement of chromosome 1. Doubl e minutes and unidentifiable markers was also observed. The most frequent s econdary changes included add(4)(q35), add(ll)(p13), add(14)(q32), add(16)( q12). add(17)(p13), add(19)(q12) and add(21)(q22). Minority of cases showed deletions and translocations. Ploidy pattern ranged from diploid to hypote traploid. The present study substantiates aberration of chromosome I in the form of deletions, additions, duplications and iso-chromosome with some no table secondary abnormalities. (C) 2001 Editions scientifiques et medicales Elsevier SAS.