Tc-99m MDP, thallium-201 chloride and Tc-99m MAG3 renal uptake in subacuteand chronic radiation nephritis compared

The authors present a comparison of the findings for thallium-201 (Tl-201), Tc-99m MAG3 and Tc-99m MDP in subacute and chronic radiation nephritis. in a 9-yr-old boy who was treated by radiation therapy for alveolar rhabdomyo sarcoma of the left chest wall by a radiation port that partially included the left kidney. TI-201 imaging three and six months later showed a cortica l defect in the left kidney due to radiation nephritis. Tc-99m MDP scan sho wed increased uptake on both occasions, but more marked in the subacute per iod than in the chronic period. Tc-99m MAG3 showed decreased concentration and increased cortical retention three months later. Six months after the r adiation therapy, a cortical defect corresponding to the cortical area that showed increased parenchymal retention was more prominent in the Tc-99m MA G3 scan. In the present case, Tc-99m MDP, Tl-201 and Tc-99m MAG3 findings may provid e useful information for understanding pathophysiological damage in the kid ney after radiation.