Prevention of anterior glottic restenosis in a canine model with topical mitomycin-C

To develop a model for recurrent anterior glottic stenosis and to test the efficacy of topical mitomycin-C in preventing restenosis., we induced anter ior glottic stenosis with a CO2 laser in 5 dogs. In 3 dogs, recurrence was established after surgical lysis. Subsequently, the 3 dogs received a singl e topical 3-minute treatment with a 1% solution of mitomycin-C after a seco nd surgical lysis. In a parallel experiment, the other 2 dogs received a si ngle topical 3-minute treatment with a 1% solution of mitomycin-C after the initial surgical lysis. An anterior glottic web was induced in all 5 dogs with the CO2 laser. The 3 dogs experienced restenosis at the anterior glott is after surgical lysis alone, Mitomycin-C prevented anterior glottic reste nosis in 2 of the 3 dogs treated twice and in both of the dogs treated once (p = .02). We conclude that a recurrent stenosis of the anterior glottis m ay be induced reproducibly in the canine model with the CO2 laser. Applicat ion of topical mitomycin-C after lysis of an anterior glottic stenosis prod uces a statistically significant reduction in the rate of restenosis as com pared to surgical lysis alone.