Pure sesame oil vs isotonic sodium chloride solution as treatment for dry nasal mucosa

Objective: To evaluate whether there was any difference in efficacy when na sal mucosa dryness was treated with pure sesame oil (Nozoil) compared with isotonic sodium chloride solution (ISCS). Design: In a randomized, crossover study, 79 subjects with nasal mucosa dry ness were enrolled. Half the subjects received pure sesame oil for 14 days followed by ISCS for 14 days, and the other half received ISCS for 14 days followed by pure sesame oil for 14 days. During the test period from March 13 to May 30, 2000, the outdoor absolute humidity was low. Nasal mucosa dry ness, stuffiness, and crusts were scored every evening with a visual analog scale. Setting: The County Hospital, Skelleftea, Sweden Results: Nasal mucosa dryness improved significantly when pure sesame oil w as used compared with ISCS (P < .001). The improvement in nasal stuffiness was also better with pure sesame oil (P < .001) as was improvement in nasal crusts (P < .001). Eight of 10 subjects reported that their nasal symptoms had improved with pure sesame oil compared with 3 of 10 for ISCS (P < .001 ). Adverse events were few and temporary. Conclusion: When nasal mucosa dryness due to a dry winter climate was treat ed, pure sesame oil was shown statistically to be significantly more effect ive than ISCS.