Aggregation of insulin by chlorpromazine

Authors
Bhattacharyya, J Das, KP
Citation
J. Bhattacharyya et Kp. Das, Aggregation of insulin by chlorpromazine, BIOCH PHARM, 62(9), 2001, pp. 1293-1297
Citations number
9
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOCHEMICAL PHARMACOLOGY
ISSN journal
00062952 → ACNP
Volume
62
Issue
9
Year of publication
2001
Pages
1293 - 1297
Database
ISI
SICI code
0006-2952(20011101)62:9<1293:AOIBC>2.0.ZU;2-E
Abstract
Chlorpromazine (CPZ) is known to induce hyperglycaemia and can inhibit insu lin secretion in both normal subjects and patients with latent diabetes mel litus. In this study, we have tried to determine a probable mechanism by wh ich CPZ causes hyperglycaemia. It is possible that CPZ causes insulin aggre gation by the reduction of disulphide bonds, thereby inactivating insulin a nd hence causing hyperglycaemia. (C) 2001 Elsevier Science Inc. All rights reserved.