Studies on alpha(1 -> 5) linked octyl arabinofuranosyl disaccharides for mycobacterial arabinosyl transferase activity

Authors
Pathak, AK Pathak, V Maddry, JA Suling, WJ Gurcha, SS Besra, GS Reynolds, RC
Citation
Ak. Pathak et al., Studies on alpha(1 -> 5) linked octyl arabinofuranosyl disaccharides for mycobacterial arabinosyl transferase activity, BIO MED CH, 9(12), 2001, pp. 3145-3151
Citations number
45
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
9
Issue
12
Year of publication
2001
Pages
3145 - 3151
Database
ISI
SICI code
0968-0896(200112)9:12<3145:SOA-5L>2.0.ZU;2-8
Abstract
The appearance multi-drug resistant Mycobacterium tuberculosis (MTB) throug hout the world has prompted a search for new. safer and more active agents against tuberculosis. Based on studies of the biosynthesis of mycobacterial cell wall polysaccharides, octyl 5-O-(alpha -D-arabinofuranosyl)-alpha -D- arabinofuranoside analogues were synthesized and evaluated as inhibitors fo r Al. tuberculosis and Mycobacterium avium. A cell free assay system has be en used for the evaluation of these disaccharides as substrates for mycobac terial arabinosyltransferase activity. (C) 2001 Elsevier Science Ltd. All r ights reserved.