Citation
R. Garg et al., Possible allosteric effects in anticancer compounds, BIO MED CH, 9(12), 2001, pp. 3161-3164
Citations number
8
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896
→ ACNP
Volume
9
Issue
12
Year of publication
2001
Pages
3161 - 3164
Database
ISI
SICI code
0968-0896(200112)9:12<3161:PAEIAC>2.0.ZU;2-C
Abstract
We have found in this report. and an earlier one, that in a variety of inst
ances an inverted parabolic relationship between biological activity and CM
R or logP is observed. That is, activity first decreases as CMR or logP inc
reases and then turns about and increases. This could be attributed to the
ligands causing a change in the receptor structure. The present report cons
iders QSAR for a variety of resistant and sensitive cancer cells. (C) 2001
Elsevier Science Ltd. All rights reserved.