6-(4-benzylpiperazin-1-yl)benzodioxanes as selective ligands at cloned primate dopamine D-4 receptors

Authors
Hodgetts, KJ Kieltyka, A Brodbeck, R Tran, JN Wasley, JWF Thurkauf, A
Citation
Kj. Hodgetts et al., 6-(4-benzylpiperazin-1-yl)benzodioxanes as selective ligands at cloned primate dopamine D-4 receptors, BIO MED CH, 9(12), 2001, pp. 3207-3213
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
9
Issue
12
Year of publication
2001
Pages
3207 - 3213
Database
ISI
SICI code
0968-0896(200112)9:12<3207:6ASLAC>2.0.ZU;2-J
Abstract
A series of novel 6-(4-benzylpiperazin-1-yl)benzodioxanes were prepared and screened at selected dopamine receptor subtypes. 6-(4-[4-Chlorobenzyl]pipe razin-1-yl)benzodioxane (2d) had high affinity and selectivity for the D-4 dopamine receptor subtype and was identified as a D-4 antagonist via its at tenuation of dopamine-induced GT gamma S-35 binding at the D-4 receptor. (C ) 2001 Elsevier Science Ltd. All rights reserved.