QSAR of the inhibition of angiogenesis by TNP-470 and ovalicin analogues: Another example of an allosteric interaction

Authors
Mekapati, SB Hansch, C
Citation
Sb. Mekapati et C. Hansch, QSAR of the inhibition of angiogenesis by TNP-470 and ovalicin analogues: Another example of an allosteric interaction, BIO MED CH, 9(12), 2001, pp. 3225-3230
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
9
Issue
12
Year of publication
2001
Pages
3225 - 3230
Database
ISI
SICI code
0968-0896(200112)9:12<3225:QOTIOA>2.0.ZU;2-R
Abstract
QSAR have been formulated for variations of TNP-470 and Ovalicin on various cell lines. In the examples of mouse lymphocyte cells and bovine endotheli al cells the results suggest an allosteric interaction. These results are c ompared with the binding of nitrobenzene to hemoglobin in rats in vivo. Suc h a reaction does not occur with methionine aminopeptidase. (C) 2001 Elsevi er Science Ltd. All rights reserved.