Plasmodium falciparum erythrocyte membrane protein 1 functions as a ligandfor P-selectin

Citation
Am. Senczuk et al., Plasmodium falciparum erythrocyte membrane protein 1 functions as a ligandfor P-selectin, BLOOD, 98(10), 2001, pp. 3132-3135
Citations number
23
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
BLOOD
ISSN journal
00064971 → ACNP
Volume
98
Issue
10
Year of publication
2001
Pages
3132 - 3135
Database
ISI
SICI code
0006-4971(20011115)98:10<3132:PFEMP1>2.0.ZU;2-1
Abstract
The malarial protein Plasmodium falciparum erythrocyte membrane protein 1 ( PfEMP1) is a parasite protein that is exported to the surface of the infect ed erythrocyte, where it is inserted into the red cell cytoskeleton in the second half of the parasite life cycle. The surface expression of PfEMP1 co incides with the occurrence of the adhesion of infected erythrocytes to vas cular endothelium. This protein has been shown to interact with CD36, inter cellular adhesion molecule-1 (ICAM-1) and chondroitin sulfate A (CSA). In t his study, it is demonstrated by affinity purification and western blot ana lysis that PfEMP1 also functions as a cell surface ligand for P-selectin, a n adhesion molecule that has been shown to mediate the rolling of infected erythrocytes under physiologic flow conditions, leading to a significant In crease in adhesion to CD36 on activated platelets and microvascular endothe lium. (C) 2001 by The American Society of Hematology.