EFFECTS OF AGING ON THE CEREBRAL DISTRIBUTION OF TC-99M HEXAMETHYLPROPYLENE AMINE OXIME IN HEALTHY HUMANS

Some brain functions decline at a linear rate throughout adulthood. Ot hers remain relatively stable until very late in the life cycle. This study characterized the effects of aging on the regional cerebral dist ribution of hexamethylpropylene amine oxime (HMPAO) in healthy human v olunteers. The sample consisted of 26 men and 18 women with a mean age of 41.6+/-14.9 years (range: 19-73). Their past medical histories, ph ysical examinations, and laboratory screening tests were normal. Singl e-photon emission tomography (SPET) scans of the brain were performed with a standardized acquisition and processing protocol on a triple-he aded camera equipped with fan beam collimators. A 3-D restorative filt er and a correction for uniform attenuation were applied before the im ages were reinterpolated in planes parallel to the line connecting the frontal and occipital poles. Mean counts per pixel were measured in m ultiple regions of interest (ROIs) within each hemisphere by custom fi tting a set of templates to the images. The mean activity in each ROI was compared with the mean activity per pixel in the whole brain. Regr ession analyses were used to relate the activity ratios to age with bo th linear and nonlinear models. The relative concentration of radioact ivity decreased significantly with age in most, but not all, gray matt er structures. It increased in the white matter regions. The nonlinear model of aging fit the data significantly better than a straight line did. Most of the changes with age occurred during young adulthood. No further changes were detectable after the onset of middle age. The me dian breakpoint age at which the rate of change became negligible was 36.6 years. Aging significantly affects the relative uptake of HMPAO i n healthy humans. It decreases in many gray matter regions and increas es in most white matter regions. However, the changes do not appear to be linear. Most seem to occur during young adulthood before people re ach their late thirties, The distribution then appears to remain relat ively stable throughout middle age.