INTERACTIONS OF NAPROXEN WITH VINYLPYRROLIDONE AND BETA-CYCLODEXTRIN - A FLUOROMETRIC STUDY

A spectrofluorimetric method to study the interactions of naproxen wit h 1-vinyl-2-pyrrolidone and beta-cyclodextrin in aqueous solution has been proposed. As complexation causes appreciable spectral changes, th is method enables the determination of the stability constants. Comple xation with beta-cyclodextrin results in an enhancement of the fluores cence of naproxen whereas 1-vinyl-2-pyrrolidone involves a quenching o f fluorescence. It has been supposed 1:1 complex formation. Specifical ly, formation constants, enthalpy and entropy values have been obtaine d for the aforementioned complexes at different temperatures and pH va lues; their associated errors are given. (C) 1997 Elsevier Science B.V .