A patient being treated for sickle cell crisis developed swollen, painful,
indurated, discoloured thighs after several days in hospital. Imaging revea
led the presence of multiple small abscesses in the muscle and methicillin
resistant Staphylococcus aureus (MRSA) was cultured from aspirated fluid. P
yomyositis usually occurs in association with damaged muscle and impaired h
ost defences. Staphylococcus is the most frequent organism involved. It is
not a common complication of sickle cell disease, although it may be under
diagnosed. Availability of advanced imaging techniques facilitates early di
agnosis of pyomyositis.